Slow Visual Studio 2010 tab closing
If you experience this issue try to add your project’s folder to your antivirus location exception. I have Microsoft Security Essentials and this slowness irritated me for quite some time until I accidentally found on some forum this advice. And it really helped me (after reboot, actually, but I think it depends on antivirus).
Hope it helps you as well.
Update: just found interesting discussion on VS performanve optimizations on StackOverflow.com: Visual Studio Optimizations.